Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31710619 | 1.00 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL30228588 | 0.90 | MEN1 (0.51) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL30228272 | 0.89 | CHRM2 (0.51) | ALDH1A1HPGDL3MBTL1HSD17B10HTT | |
| SCHEMBL30228280 | 0.89 | CHRM2 (0.51) | ALDH1A1HPGDL3MBTL1HSD17B10HTT | |
| SCHEMBL31711057 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL30228346 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL31711268 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL31710963 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL30228046 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 | |
| SCHEMBL30228467 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |