Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGLV6-57 | P01721 | 6/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31710568 | 0.87 | IGLV6-57 (0.52) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30227891 | 0.80 | IGLV6-57 (0.43) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228402 | 0.80 | IGLV6-57 (0.46) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228077 | 0.79 | KCNA3 (0.56) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228360 | 0.78 | IGLV6-57 (0.47) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228207 | 0.78 | IGLV6-57 (0.47) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228594 | 0.78 | IGLV6-57 (0.45) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228039 | 0.78 | IGLV6-57 (0.46) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30228123 | 0.78 | IGLV6-57 (0.51) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD | |
| SCHEMBL30227938 | 0.78 | IGLV6-57 (0.51) | IGLV6-57KCNA3HSD17B3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | IGLV6-57 4814/4885KCNA3 4258/4885HSD17B3 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.