Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 8/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30370293 | 0.86 | HDAC1 (0.54) | MAP3K7TAB1USP30HDAC1HDAC6 | |
| SCHEMBL25676535 | 0.86 | USP30 (0.52) | USP30 | |
| SCHEMBL25675488 | 0.81 | CA12 (0.49) | PIM1HDAC1HDAC6KCNH2 | |
| SCHEMBL30230922 | 0.80 | HDAC1 (0.43) | PIM1HDAC1HDAC6 | |
| SCHEMBL30060169 | 0.80 | HDAC1 (0.43) | PIM1HDAC1HDAC6 | |
| SCHEMBL25144728 | 0.79 | USP30 (0.42) | USP30PIM1HDAC1HDAC6PRKDC | |
| SCHEMBL25144570 | 0.79 | USP30 (0.42) | USP30PIM1HDAC1HDAC6PRKDC | |
| Trifluoroacetic Acid SCHEMBL30061795 | 0.77 | HDAC1 (0.42) | PIM1HDAC1HDAC6 | |
| SCHEMBL27418109 | 0.77 | USP30 (0.56) | USP30HDAC1HDAC6 | |
| SCHEMBL30060184 | 0.77 | HDAC1 (0.40) | USP30PIM1HDAC1HDAC6PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132925-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2023-02-15 | — | — | EP | disclosed |