Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27418109 | 0.88 | USP30 (0.56) | HDAC1HDAC6RIPK1USP30 | |
| SCHEMBL30230685 | 0.86 | MAP3K7 (0.42) | HDAC1HDAC6USP30KCNH2MAP3K7 | |
| SCHEMBL25676690 | 0.85 | USP30 (0.54) | HDAC1HDAC6USP30 | |
| SCHEMBL31017667 | 0.85 | USP30 (0.54) | HDAC1HDAC6USP30 | |
| SCHEMBL30370273 | 0.84 | ADCY1 (0.44) | USP30KCNH2TEAD1EPHX2 | |
| SCHEMBL25305510 | 0.78 | HDAC1 (0.50) | HDAC1HDAC6RIPK1GRIN1GRIN2B | |
| SCHEMBL25258959 | 0.78 | HDAC1 (0.50) | HDAC1HDAC6GRIN1GRIN2BCYP2C9 | |
| SCHEMBL25258088 | 0.78 | HDAC1 (0.50) | HDAC1HDAC6RIPK1GRIN1GRIN2B | |
| SCHEMBL28971352 | 0.78 | HDAC1 (0.50) | HDAC1HDAC6RIPK1GRIN1GRIN2B | |
| SCHEMBL24073259 | 0.78 | HDAC1 (0.51) | HDAC1HDAC6USP30GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |