Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.55 |
| ▸ | AGER | Q15109 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231521 | 0.86 | AR (0.55) | ARAGERCA12CA1CA2 | |
| SCHEMBL30231545 | 0.84 | MAPT (0.57) | CA12CA1CA2CA6CA5A | |
| SCHEMBL30231424 | 0.82 | KCNA3 (0.53) | CA12CA1CA2CA6CA5A | |
| SCHEMBL12722470 | 0.81 | MAOB (0.71) | CA12CA1CA2CA6CA5A | |
| SCHEMBL30231574 | 0.79 | CA12 (0.50) | CA12CA1CA2CA6CA5A | |
| SCHEMBL28722650 | 0.76 | MAOB (0.71) | CA12CA1CA2CA6CA7 | |
| SCHEMBL3078232 | 0.76 | CA12 (0.69) | CA12CA9ALDH1A1HPGDKMT2A | |
| SCHEMBL30231399 | 0.76 | CA12 (0.52) | CA12CA1CA2CA6CA5A | |
| SCHEMBL30231641 | 0.76 | CA12 (0.49) | ARCA12CA1CA2CA6 | |
| SCHEMBL238765 | 0.74 | AGER (0.70) | ARAGER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |