Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA6 | P23280 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20847991 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL30360979 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL30762863 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL20839167 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL30228096 | 0.78 | CA12 (0.48) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL20839359 | 0.78 | ALDH1A1 (0.45) | CA12CA9KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL20839145 | 0.78 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDHSD17B10AR | |
| SCHEMBL20848064 | 0.78 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDHSD17B10AR | |
| SCHEMBL20839318 | 0.78 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL30228411 | 0.78 | ALPL (0.43) | CA12CA2CA9KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |