Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231961 | 0.89 | MAPT (0.56) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231614 | 0.89 | HPGD (0.60) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231266 | 0.87 | SIGMAR1 (0.57) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231690 | 0.86 | ALDH1A1 (0.58) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231424 | 0.86 | KCNA3 (0.53) | MAPTL3MBTL1KMT2AALDH1A1HPGD | |
| SCHEMBL30231695 | 0.86 | ALDH1A1 (0.58) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL12722470 | 0.85 | MAOB (0.71) | RAB9AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL30231631 | 0.85 | NOD2 (0.51) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231574 | 0.85 | CA12 (0.50) | MAPTL3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL30231399 | 0.84 | CA12 (0.52) | MAPTL3MBTL1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |