Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227919 | 0.85 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL30231670 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL30231669 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL30231646 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL30231686 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDMAPTRECQL | |
| SCHEMBL30360852 | 0.80 | CYP3A4 (0.62) | ALDH1A1KDM4EHPGDL3MBTL1CYP3A4 | |
| SCHEMBL31089779 | 0.76 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDL3MBTL1CYP3A4 | |
| SCHEMBL21629566 | 0.76 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDL3MBTL1CYP3A4 | |
| SCHEMBL31711159 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL20839474 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |