Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231670 | 1.00 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL30231646 | 0.89 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL30231686 | 0.89 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL30231689 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL30227915 | 0.83 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL21630173 | 0.82 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4ERECQLRXFP1 | |
| SCHEMBL30231748 | 0.78 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4EMAPTPOLB | |
| SCHEMBL30231429 | 0.76 | MAP1LC3B (0.55) | ALDH1A1HPGDKDM4EMAPTPOLB | |
| SCHEMBL21629591 | 0.74 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ERECQLMAPT | |
| SCHEMBL21629565 | 0.73 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4ERECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |