Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231670 | 0.89 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDKDM4ERECQL | |
| SCHEMBL30231669 | 0.89 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDKDM4ERECQL | |
| SCHEMBL30231686 | 0.86 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDKDM4ERECQL | |
| SCHEMBL30228241 | 0.84 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDKDM4EMAPK1 | |
| SCHEMBL21629598 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPTHPGDKDM4ERECQL | |
| SCHEMBL30231689 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDKDM4ERECQL | |
| SCHEMBL30231429 | 0.74 | MAP1LC3B (0.55) | ALDH1A1MAPTHPGDKDM4EMAPK1 | |
| SCHEMBL21629535 | 0.73 | ALDH1A1 (0.79) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL21629532 | 0.73 | ALDH1A1 (0.79) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL30231748 | 0.73 | ALDH1A1 (0.66) | ALDH1A1MAPTHPGDKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |