Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231772 | 0.89 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231662 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231695 | 0.88 | ALDH1A1 (0.58) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231614 | 0.87 | HPGD (0.60) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231545 | 0.86 | MAPT (0.57) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231961 | 0.85 | MAPT (0.56) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30231266 | 0.83 | SIGMAR1 (0.57) | ALDH1A1HPGDSMN1; SMN2USP2KMT2A | |
| SCHEMBL30228338 | 0.81 | KCNA3 (0.50) | ALDH1A1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL20839059 | 0.80 | ALDH1A1 (0.77) | ALDH1A1HPGDUSP2KMT2ATDP1 | |
| SCHEMBL20839056 | 0.80 | ALDH1A1 (0.77) | ALDH1A1HPGDUSP2KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |