Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25449219 | 0.79 | MAPT (0.77) | ALDH1A1HPGDMAPK1ALOX15TSHR | |
| SCHEMBL4482108 | 0.79 | SMN1; SMN2 (0.66) | ALDH1A1HPGDABCB1MAPK1ALOX15 | |
| SCHEMBL27915651 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDABCB1MAPK1MAPT | |
| SCHEMBL30231669 | 0.78 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTKDM4EHSD17B10 | |
| SCHEMBL30231670 | 0.78 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTKDM4EHSD17B10 | |
| SCHEMBL30231625 | 0.77 | MAP1LC3B (0.74) | ALDH1A1HPGDMAPK1ALOX15TSHR | |
| SCHEMBL28805341 | 0.77 | ABCB1 (0.50) | ALDH1A1HPGDABCB1MAPK1TSHR | |
| SCHEMBL21630173 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HPGDMAPK1ALOX15TSHR | |
| SCHEMBL30231539 | 0.74 | IGLV6-57 (0.44) | ALDH1A1HPGDMAPTKDM4EHSD17B10 | |
| SCHEMBL21629591 | 0.73 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |