Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535587 | 1.00 | KEAP1 (0.48) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| Potassium SCHEMBL1843363 | 0.98 | KEAP1 (0.47) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL21195978 | 0.84 | LMNA (0.41) | KEAP1NFE2L2ALDH1A1LMNACASP1 | |
| SCHEMBL31364654 | 0.84 | LMNA (0.41) | KEAP1NFE2L2ALDH1A1LMNACASP1 | |
| SCHEMBL24402344 | 0.82 | SMN1; SMN2 (0.41) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL535611 | 0.81 | KDM4E (0.47) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL535620 | 0.81 | KDM4E (0.39) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL31330687 | 0.81 | KDM4E (0.39) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL30495159 | 0.81 | KDM4E (0.39) | KEAP1NFE2L2KDM4ETDP1CYP3A4 | |
| SCHEMBL30067156 | 0.81 | KEAP1 (0.46) | KEAP1NFE2L2KDM4ETDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| CN-115397512-B | As AHR antagonists Pyridopyrimidinone derivatives | 先达生物科技公司 | 2024-12-17 | — | — | CN | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |
| CN-115397512-A | Pyridopyrimidinone derivatives as AHR antagonists | 先达生物科技公司 | 2022-11-25 | — | — | CN | disclosed |