Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535620 | 1.00 | KDM4E (0.39) | KDM4ECYP3A4GLAKEAP1NFE2L2 | |
| SCHEMBL535621 | 0.81 | KDM4E (0.41) | KDM4ECYP3A4GLAGAAMAPT | |
| SCHEMBL535587 | 0.81 | KEAP1 (0.48) | KDM4ECYP3A4KEAP1NFE2L2MAPT | |
| SCHEMBL30232992 | 0.81 | KEAP1 (0.48) | KDM4ECYP3A4KEAP1NFE2L2MAPT | |
| SCHEMBL25360740 | 0.80 | CFTR (0.41) | KDM4ECYP3A4GAASMN1; SMN2USP2 | |
| SCHEMBL31656690 | 0.80 | CFTR (0.41) | KDM4ECYP3A4GAASMN1; SMN2USP2 | |
| SCHEMBL536169 | 0.80 | KDM4E (0.50) | KDM4EGLAGAAMAPTALDH1A1 | |
| Potassium SCHEMBL1843363 | 0.79 | KEAP1 (0.47) | KDM4ECYP3A4KEAP1NFE2L2MAPT | |
| SCHEMBL535611 | 0.78 | KDM4E (0.47) | KDM4ECYP3A4KEAP1NFE2L2GAA | |
| SCHEMBL31558258 | 0.78 | KDM4E (0.39) | KDM4ECYP3A4GLAKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2025101598-A1 | BI-CYCLIC PYRIMIDINE COMPOUNDS, METHODS AND USES THEREOF | ZENO MANAGEMENT, INC. (US) | 2025-05-15 | — | — | WO | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |