Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23883903 | 1.00 | KDM1A (0.41) | KDM1AMAPK14L3MBTL1LMNALRRK2 | |
| SCHEMBL30335270 | 0.78 | CTSV (0.44) | KDM1AMAPK14L3MBTL1LMNALRRK2 | |
| SCHEMBL23883904 | 0.78 | CTSV (0.44) | KDM1AMAPK14L3MBTL1LMNALRRK2 | |
| SCHEMBL26133457 | 0.77 | MRGPRX4 (0.48) | KDM1AMAPK14L3MBTL1PTGER1MAPT | |
| SCHEMBL4540283 | 0.76 | KDM1A (0.56) | KDM1AMAPK14L3MBTL1LMNALRRK2 | |
| SCHEMBL23883871 | 0.76 | KDM1A (0.49) | KDM1AMAPK14L3MBTL1LRRK2PTGER1 | |
| SCHEMBL30335518 | 0.76 | KDM1A (0.49) | KDM1AMAPK14L3MBTL1LRRK2PTGER1 | |
| SCHEMBL23899806 | 0.74 | HTR1A (0.43) | KDM1AMAPK14L3MBTL1LMNALRRK2 | |
| SCHEMBL23899537 | 0.74 | KDM1A (0.50) | KDM1AMAPK14L3MBTL1LRRK2PTGER1 | |
| SCHEMBL30234551 | 0.72 | CTSV (0.45) | KDM1AMAPK14L3MBTL1LRRK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132908-A1 | INDOLE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD) | Vertex Pharmaceuticals Incorporated (US) | 2023-02-15 | — | — | EP | disclosed |