Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.75 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024151 | 1.00 | CYP1B1 (0.75) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16810381 | 0.87 | CYP1A1 (0.73) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1322027 | 0.86 | CYP1A1 (0.82) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1322029 | 0.86 | CYP1A1 (0.82) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1604142 | 0.86 | CYP1A1 (0.77) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31436361 | 0.86 | CYP1A1 (0.77) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31436369 | 0.86 | CYP1A1 (0.77) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL979408 | 0.86 | CYP1B1 (1.00) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20570877 | 0.86 | CYP1A1 (0.82) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9503680 | 0.86 | CYP1B1 (1.00) | CYP1B1CYP1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9162991-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITY OF OTTAWA (CA) | 2015-10-20 | — | — | US | disclosed |
| US-20140024837-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2014-01-23 | — | — | US | disclosed |
| US-8614233-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITE DE MONTREAL (CA) | 2013-12-24 | — | — | US | disclosed |
| US-20100204280-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204280-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | TGM2, TGM3, TGM1 | CYP1B1 4160/4885CYP1A1 4506/4885CYP1A2 4198/4885 |
| US-20140024837-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | TGM2, TGM3, TFPI | CYP1B1 3940/4885CYP1A1 4421/4885CYP1A2 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.