Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170959 | 0.83 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAKDM4EMAPTKMT2A | |
| SCHEMBL14539758 | 0.83 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAKDM4EMAPTKMT2A | |
| SCHEMBL16841453 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2CES2GAAKDM4EMAPT | |
| SCHEMBL6476226 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2CES2GAAKDM4EMAPT | |
| SCHEMBL17803093 | 0.78 | CES2 (0.37) | CES2CYP2D6 | |
| SCHEMBL19014336 | 0.73 | GAA (0.32) | SMN1; SMN2GAAKDM4EMAPTKMT2A | |
| SCHEMBL17802920 | 0.73 | CHRNB2 (0.48) | SMN1; SMN2 | |
| SCHEMBL10788281 | 0.73 | GLA (0.39) | SMN1; SMN2KDM4EMAPTKMT2AATM | |
| SCHEMBL7715567 | 0.73 | KDM4E (0.40) | SMN1; SMN2GAAKDM4EMAPTKMT2A | |
| SCHEMBL7715570 | 0.73 | KDM4E (0.40) | SMN1; SMN2GAAKDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390727-A | N-linked isoquinolinamides as LRRK2 inhibitors, pharmaceutical compositions and uses thereof | 默沙东有限责任公司 | 2023-07-04 | — | — | CN | claimed |
| EP-4408427-A1 | SYSTEM AND METHOD FOR STATIC AND DYNAMIC MRI SHIMMING | Merck Sharp & Dohme LLC (US) | 2024-08-07 | — | — | EP | disclosed |
| WO-2023055679-A1 | C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-04-06 | — | — | WO | disclosed |