Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | HSD17B13 | Q7Z5P4 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2969531 | 0.89 | EPHX2 (0.52) | ROCK2ROCK1EPHX2PPARGHSD17B13 | |
| SCHEMBL3032935 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1EPHX2PPARGHSD17B13 | |
| SCHEMBL3029239 | 0.75 | ROCK2 (0.54) | ROCK2ROCK1EPHX2PPARGHSD17B13 | |
| SCHEMBL3470919 | 0.75 | EPHX2 (0.54) | ROCK2ROCK1EPHX2PPARG | |
| SCHEMBL3025646 | 0.74 | EPHX2 (0.51) | ROCK2ROCK1EPHX2PPARGHDAC6 | |
| SCHEMBL13218656 | 0.74 | ROCK2 (0.53) | ROCK2ROCK1EPHX2PPARGHSD17B13 | |
| SCHEMBL13112865 | 0.74 | HPGD (0.56) | ROCK2ROCK1LMNATP53HTT | |
| SCHEMBL2906841 | 0.73 | EPHX2 (0.52) | ROCK2ROCK1EPHX2PPARGLMNA | |
| SCHEMBL3579975 | 0.73 | PTGER1 (0.62) | ROCK2ROCK1HDAC6HTR2CHTR2B | |
| SCHEMBL3729487 | 0.72 | PTPN1 (0.45) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210655-A1 | NOVEL sEH INHIBITORS AND THEIR USE | GLAXOSMITHKLINE LLC | 2010-08-19 | — | — | US | claimed |
| US-20100210655-A1 | NOVEL sEH INHIBITORS AND THEIR USE | GLAXOSMITHKLINE LLC | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210655-A1 | NOVEL sEH INHIBITORS AND THEIR USE | EPHX1, NCEH1, FAH | ROCK2 396/4885ROCK1 226/4885EPHX2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.