Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29603392 | 1.00 | MAOA (0.58) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL27492216 | 0.98 | MAOA (0.59) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL7551216 | 0.98 | MAOA (0.59) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| SCHEMBL4794961 | 0.87 | MAOA (0.52) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| Acetic Acid SCHEMBL1666949 | 0.87 | NOTUM (0.59) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| SCHEMBL21020930 | 0.86 | TSHR (0.50) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| SCHEMBL6261159 | 0.82 | MAOA (0.44) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11434377 | 0.79 | MAOA (0.46) | MAOAMAOBTMPRSS2HTR1AADRA2A | |
| SCHEMBL28743871 | 0.78 | MEN1 (0.48) | HTR1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL29390912 | 0.73 | MAOA (1.00) | MAOAMAOBHTR1AADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104744476-B | IMIDAZOPYRAZINE Syk INHIBITORS | 吉利德康涅狄格公司 | 2017-04-12 | — | — | CN | claimed |
| EP-2793890-A1 | SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-10-29 | — | — | EP | claimed |
| WO-2014160177-A2 | QUINAZOLINE INHIBITORS OF PI3K | EXELIXIS, INC. (US) | 2014-10-02 | — | — | WO | claimed |
| WO-2013096150-A1 | SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | claimed |
| CN-102459264-A | Pyrimidine inhibitors of kinase activity | ABBOTT LAB | 2012-05-16 | — | — | CN | claimed |
| JP-2012500853-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | claimed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | claimed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-0324184-B1 | 2-Amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1994-09-28 | — | — | EP | claimed |
| CN-1022917-C | Process for preparing 2-amino-tetrahydro-isoquinoline derivatives | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1993-12-01 | — | — | CN | claimed |
| WO-1992000981-A1 | NOVEL 3-SUBSTITUTED CEPHEM COMPOUNDS AND PROCESSES FOR PREPARATION THEREOF | DAE WOONG PHARMACEUTICAL CO., LTD. (KR) | 1992-01-23 | — | — | WO | claimed |
| CN-1035502-A | Derivative and preparation method thereof, and the pharmaceutical preparation 2-amino-tetrahydrochysene-different quinoline woods that contains this derivative | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1989-09-13 | — | — | CN | claimed |
| JP-1213266-A | — | — | None | — | — | JP | disclosed |
| EP-4367123-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | Glenmark Specialty S.A. (CH) | 2024-05-15 | — | — | EP | disclosed |
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| EP-0112511-A2 | New compounds, pharmaceutical preparations containing same and process for their preparation | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-07-04 | — | — | EP | disclosed |
| US-4221798-A | Hypotensive 2-heterocycloamino-imidazolines | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1980-09-09 | — | — | US | disclosed |
| US-3846412-A | DIHYDRO-2-AMINO-ISOQUINOLINES AND THEIR DERIVATIVES | LEPETIT SPA | 1974-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | MAOA 2401/4885MAOB 2125/4885TMPRSS2 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.