Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20911220 | 1.00 | HSP90AA1 (0.44) | HSP90AA1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL28996013 | 0.81 | ASIC3 (0.52) | HSP90AA1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL17755588 | 0.78 | PIM1 (0.45) | HTTRECQLPIM1NISCHCYP3A4 | |
| SCHEMBL29454745 | 0.78 | NISCH (0.50) | HSP90AA1HTTRECQLKDM4EPIM1 | |
| SCHEMBL78566 | 0.78 | NISCH (0.50) | HSP90AA1HTTRECQLKDM4EPIM1 | |
| SCHEMBL29598957 | 0.78 | NISCH (0.50) | HSP90AA1HTTRECQLKDM4EPIM1 | |
| SCHEMBL22334571 | 0.76 | PIK3CD (0.45) | HSP90AA1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL902145 | 0.76 | KARS1 (0.44) | HSP90AA1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL31372462 | 0.75 | NISCH (0.48) | HSP90AA1HTTRECQLKDM4EPIM1 | |
| SCHEMBL14053846 | 0.75 | NISCH (0.48) | HSP90AA1HTTRECQLKDM4EPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651358-B | 4-aminopyridine derivative, pharmaceutical composition, preparation method and application thereof | 上海迪诺医药科技有限公司 | 2023-04-07 | — | — | CN | disclosed |