Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 15/20 | 0.46 |
| ▸ | HPGD | P15428 | 14/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25737761 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL25733561 | 0.96 | ROCK2 (0.41) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL31731027 | 0.96 | ROCK2 (0.41) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL30439891 | 0.92 | HDAC1 (0.43) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL25275428 | 0.92 | HDAC1 (0.43) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL25733565 | 0.90 | PDE10A (0.40) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL30902946 | 0.90 | PDE10A (0.40) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL31730904 | 0.90 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL25733566 | 0.90 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL25235973 | 0.88 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119031913-A | Purine and methods of use thereof | 奇尼塔公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4444312-A2 | PURINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107552-A2 | PURINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
| EP-4161519-A1 | PURINES AND METHODS OF THEIR USE | Yumanity Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |