Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 5/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22842963 | 1.00 | GRIN2B (0.41) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL30258652 | 0.81 | ABCB1 (0.38) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20828520 | 0.76 | GRIN2B (0.47) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL30552385 | 0.75 | HDAC1 (0.51) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL26227296 | 0.75 | HDAC1 (0.51) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL19937659 | 0.75 | RAF1 (0.49) | GSK3BDYRK1A | |
| SCHEMBL31727242 | 0.74 | GRIN2B (0.48) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL2877186 | 0.74 | HCAR3 (0.57) | GRIN2BHDAC1BCL2HCAR3 | |
| SCHEMBL28658285 | 0.74 | GRIN2B (0.48) | GRIN2BHDAC1DEGS1NAMPTBCL2 | |
| SCHEMBL29651977 | 0.74 | HCAR3 (0.57) | GRIN2BHDAC1BCL2HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230087118-A1 | IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | BIOGEN MA INC. | 2023-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230087118-A1 | IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | IRAK4, IRAK2, IRAK1 | GRIN2B 3015/4885HDAC1 753/4885DEGS1 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.