Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3022280 | 0.85 | KCNH2 (0.46) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL13214422 | 0.85 | KDM4E (0.47) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL3025700 | 0.82 | KDM4E (0.47) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL13234527 | 0.81 | KDM4E (0.43) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL13234908 | 0.81 | KDM4E (0.43) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL13234529 | 0.80 | KCNH2 (0.51) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL23229043 | 0.74 | HSD17B10 (0.62) | HSD17B10PTGS1AKR1C3AKR1C2KDM4E | |
| SCHEMBL17967503 | 0.74 | HSD17B10 (0.77) | HSD17B10PTGS1AKR1C3AKR1C2KDM4E | |
| SCHEMBL9379551 | 0.73 | KCNH2 (0.55) | KCNH2HSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL19579751 | 0.73 | ALOX15 (0.55) | HSD17B10KDM4EHPGDALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100196476-A1 | PROCESS FOR THE PREPARATION AND PHARMACEUTICAL FORMULATIONS FOR 4-QUINOLINONES AND QUINOLINES AND USE THEREOF | FUNDACAO UNIVERSIDADE FEDERAL DE SAO CARLOS (BR) | 2010-08-05 | — | — | US | disclosed |
| EP-2167468-A2 | PROCESS FOR THE PREPARATION AND PHARMACEUTICAL FORMULATIONS FOR 4-QUINOLINONES AND QUINOLINES AND USE THEREOF | Fundação Universidade Federal De São Carlos (BR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008144865-A2 | PROCESS FOR THE PREPARATION AND PHARMACEUTICAL FORMULATIONS FOR 4-QUINOLINONES AND QUINOLINES AND USE THEREOF | FUNDAÇÃO UNIVERSIDADE FEDERAL DE SÃO CARLOS (BR) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196476-A1 | PROCESS FOR THE PREPARATION AND PHARMACEUTICAL FORMULATIONS FOR 4-QUINOLINONES AND QUINOLINES AND USE THEREOF | PF4, KCNQ1, KCNQ2 | KCNH2 367/4885HSD17B10 1593/4885PTGS1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.