Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30260445 | 0.79 | HCRTR1 (0.33) | — | |
| SCHEMBL930582 | 0.77 | SIRT6 (0.48) | SIRT6ALDH1A1JUNNFKB1NFKB2 | |
| SCHEMBL30260491 | 0.76 | SIRT6 (0.57) | SIRT6ALDH1A1JUNNFKB1NFKB2 | |
| SCHEMBL28845160 | 0.75 | SIRT6 (0.41) | SIRT6ALDH1A1 | |
| SCHEMBL1747868 | 0.74 | ALDH1A1 (0.53) | ALDH1A1POLBRAB9ANPC1GAA | |
| SCHEMBL16891679 | 0.73 | HDAC3 (0.43) | NAPRTSMN1; SMN2 | |
| SCHEMBL23214039 | 0.72 | MAPT (0.48) | SIRT6ALDH1A1RAB9AGAAKMT2A | |
| SCHEMBL20225755 | 0.72 | SIRT6 (0.41) | SIRT6ALDH1A1RAB9AKMT2A | |
| SCHEMBL30760421 | 0.72 | MAPT (0.48) | SIRT6ALDH1A1RAB9AGAAKMT2A | |
| SCHEMBL18961127 | 0.71 | NPSR1 (0.49) | SIRT6ALDH1A1POLBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715287-A | Substituted N- (methyl-d 3) pyridazine-3-carboxamide or N- (methyl-d 3) -nicotinamide compounds as IL-12, IL-23 and/or IFN alpha modulators | 百时美施贵宝公司 | 2023-02-24 | — | — | CN | disclosed |