Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 16/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267939 | 1.00 | PFKFB3 (0.58) | PFKFB3JAK2JAK3LMNA | |
| SCHEMBL30267946 | 1.00 | PFKFB3 (0.58) | PFKFB3JAK2JAK3LMNA | |
| SCHEMBL28644958 | 0.80 | PFKFB3 (0.74) | PFKFB3 | |
| SCHEMBL13727139 | 0.80 | PFKFB3 (0.69) | PFKFB3 | |
| SCHEMBL13727137 | 0.80 | PFKFB3 (0.69) | PFKFB3 | |
| SCHEMBL30268042 | 0.78 | JAK2 (0.55) | PFKFB3JAK2JAK3LMNA | |
| SCHEMBL30268170 | 0.78 | JAK2 (0.55) | PFKFB3JAK2JAK3LMNA | |
| SCHEMBL1976205 | 0.78 | PFKFB3 (0.57) | PFKFB3LMNA | |
| SCHEMBL21857650 | 0.78 | PFKFB3 (0.83) | PFKFB3 | |
| SCHEMBL28637364 | 0.77 | PFKFB3 (0.78) | PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | PFKFB3 1/4885JAK2 1459/4885JAK3 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.