SCHEMBL30274693

SCHEMBL30274693

COc1ccc(C(OC[C@H]2O[C@@H](n3c(=S)[nH]c4c(NC(=O)c5ccccc5)ncnc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 6/20 0.43
BRD4 O60885 2/20 0.37
TMIGD3 P0DMS9 2/20 0.35
TYMS P04818 1/20 0.34
TRPM2 O94759 1/20 0.34
KDR P35968 1/20 0.33
EGFR P00533 1/20 0.33
ERBB3 P21860 1/20 0.33
ADORA3 P0DMS8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30274889 1.00 TYMP (0.43) TYMPBRD4TMIGD3TYMSTRPM2
SCHEMBL29709093 0.92 TYMP (0.45) TYMPBRD4TMIGD3TYMSEGFR
SCHEMBL29709101 0.92 TYMP (0.45) TYMPBRD4TMIGD3TYMSEGFR
SCHEMBL23215660 0.92 TYMP (0.45) TYMPBRD4TMIGD3TYMSEGFR
SCHEMBL23215200 0.92 TYMP (0.45) TYMPBRD4TMIGD3TYMSEGFR
SCHEMBL3627000 0.86 TYMP (0.46) TYMPTYMS
SCHEMBL3626996 0.86 TYMP (0.46) TYMPTYMS
SCHEMBL26647641 0.85 TYMP (0.45) TYMPTYMS
SCHEMBL26647525 0.85 TYMP (0.45) TYMPTYMS
SCHEMBL30274796 0.85 TYMP (0.44) TYMPTYMSKDRADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250302995-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF SHIVALILA CHIKDU SHAKTI (US) 2025-10-02 US disclosed
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO WAVE LIFE SCIENCES LTD (SG) 2025-08-21 US disclosed
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2025-05-01 US disclosed
EP-4522744-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF Wave Life Sciences Ltd. (SG) 2025-03-19 EP disclosed
EP-4507700-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO Wave Life Sciences Ltd. (SG) 2025-02-19 EP disclosed
EP-4404942-A2 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF Wave Life Sciences Ltd. (SG) 2024-07-31 EP disclosed
WO-2023220440-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-11-16 WO disclosed
WO-2023220428-A1 COMPOSITIONS FOR EDITING ASS1 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-11-16 WO disclosed
WO-2023201095-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO WAVE LIFE SCIENCES LTD. (SG) 2023-10-19 WO disclosed
WO-2023049477-A2 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302995-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF ADAR, NSUN2, RNGTT TYMP 82/4885BRD4 3893/4885TMIGD3 4502/4885
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO ADAR, RNGTT, NSUN2 TYMP 36/4885BRD4 4771/4885TMIGD3 4420/4885
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF MECP2, ADAR, NSUN2 TYMP 1801/4885BRD4 1124/4885TMIGD3 3317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.