Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26134277 | 0.86 | GAA (0.49) | HTR2AKDM4EHTR1AHTR1BALDH1A1 | |
| SCHEMBL30274792 | 0.83 | SMN1; SMN2 (0.58) | HTR2AMTNR1AALDH1A1MAPTKMT2A | |
| SCHEMBL11536860 | 0.78 | HTR2A (0.68) | HTR2AHTR1AHTR1BMTNR1AMTNR1B | |
| SCHEMBL9532459 | 0.77 | HTR2A (0.53) | HTR2AKDM4EHTR1AMTNR1AMTNR1B | |
| SCHEMBL32669413 | 0.74 | HTR2A (0.67) | HTR2AKDM4EHTR1AHTR1BMAPT | |
| SCHEMBL27191685 | 0.74 | HTR1A (0.65) | HTR2AHTR1AHTR1BMTNR1AMTNR1B | |
| SCHEMBL27206364 | 0.74 | HTR1A (0.65) | HTR2AHTR1AHTR1BMTNR1AMTNR1B | |
| SCHEMBL10491444 | 0.74 | KMT2A (0.51) | HTR2AKDM4EHTR1AMTNR1AMTNR1B | |
| SCHEMBL13576556 | 0.74 | NQO2 (0.65) | HTR2AHTR1AHTR1BMTNR1AMTNR1B | |
| SCHEMBL10867787 | 0.74 | HTR2A (0.66) | HTR2AKDM4EHTR1AHTR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142714-A1 | N-ACETYLSEROTONIN DERIVATIVES AS TRKB ACTIVATORS AND USES THEREOF | Emory University (US) | 2023-03-08 | — | — | EP | disclosed |