Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26134277 | 0.86 | GAA (0.49) | SMN1; SMN2RAB9AHTR2AHPGDKMT2A | |
| SCHEMBL30274696 | 0.83 | HTR2A (0.57) | RAB9AHTR2AHPGDKMT2AALDH1A1 | |
| SCHEMBL11681100 | 0.80 | RAB9A (0.61) | SMN1; SMN2RAB9AHTR2AHPGDKMT2A | |
| SCHEMBL27191698 | 0.79 | CYP2C19 (0.63) | SMN1; SMN2RAB9AHTR2AHPGDADRA2A | |
| SCHEMBL10849936 | 0.76 | ADRA2A (0.64) | HTR2AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL10679736 | 0.75 | RAB9A (0.92) | SMN1; SMN2RAB9AHTR2AHPGDKMT2A | |
| SCHEMBL4098340 | 0.75 | CCR2 (0.41) | HTR2AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL4703615 | 0.74 | ACE (0.47) | RAB9AHTR2AHPGDALDH1A1HDAC8 | |
| SCHEMBL27206530 | 0.73 | CYP2C19 (0.78) | SMN1; SMN2RAB9AHTR2AADRA2AADRA2B | |
| SCHEMBL27191675 | 0.73 | CYP2C19 (0.78) | SMN1; SMN2RAB9AHTR2AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142714-A1 | N-ACETYLSEROTONIN DERIVATIVES AS TRKB ACTIVATORS AND USES THEREOF | Emory University (US) | 2023-03-08 | — | — | EP | disclosed |