SCHEMBL30276153

SCHEMBL30276153

NC(=O)c1nc(-c2c[nH]nc2C(F)(F)F)c[nH]1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCNC P24863 1/20 0.33
CDK8 P49336 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30276206 0.73 SCN9A (0.48)
SCHEMBL727645 0.70 PARP1 (0.37) CCNCCDK8
SCHEMBL31099577 0.70 CDK8 (0.36) CCNCCDK8
SCHEMBL29437668 0.70 SCN9A (0.36)
SCHEMBL28906672 0.69 ALDH1A1 (0.44)
SCHEMBL31708358 0.68 ALDH1A1 (0.42)
SCHEMBL28672231 0.65 CYP1A2 (0.30)
SCHEMBL30552824 0.65 PLK1 (0.40) CCNCCDK8
SCHEMBL4243696 0.64 MAP2K3 (0.47)
SCHEMBL5666016 0.64 ALPL (0.47) CDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115989225-A Imidazole-pyrazole derivatives as antibacterial agents 豪夫迈·罗氏有限公司 2023-04-18 CN claimed
CN-115989227-A Imidazole-pyrazole derivatives having antibacterial properties 豪夫迈·罗氏有限公司 2023-04-18 CN claimed
CN-115989225-A Imidazole-pyrazole derivatives as antibacterial agents 豪夫迈·罗氏有限公司 2023-04-18 CN disclosed
CN-115989227-A Imidazole-pyrazole derivatives having antibacterial properties 豪夫迈·罗氏有限公司 2023-04-18 CN disclosed