Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31255654 | 0.95 | SOS1 (0.43) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL25583436 | 0.92 | SOS1 (0.44) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL24735127 | 0.91 | CRBN (0.47) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL30158207 | 0.91 | CRBN (0.47) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL21409304 | 0.90 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL30009045 | 0.90 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL31697911 | 0.90 | GPR119 (0.43) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL27121298 | 0.90 | GPR119 (0.43) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL31255261 | 0.90 | CRBN (0.43) | PDE4APDE4BPDE4CPDE4DCRBN | |
| SCHEMBL21409182 | 0.89 | KMT2A (0.50) | PDE4APDE4BPDE4CPDE4DCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395828-A1 | BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER | Novartis AG (CH) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023031801-A1 | BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER | NOVARTIS AG (CH) | 2023-03-09 | — | — | WO | disclosed |