Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 11/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 2/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217760 | 0.95 | CYP3A4 (0.39) | CYP3A4EGLN2EGLN1SCN9AEPAS1 | |
| Trifluoroacetic Acid SCHEMBL3028016 | 0.87 | CYP3A4 (0.42) | CYP3A4EGLN2EGLN1F3EPAS1 | |
| Trifluoroacetic Acid SCHEMBL3022142 | 0.84 | CYP3A4 (0.39) | CYP3A4EGLN2EGLN1EPAS1SLC22A12 | |
| Trifluoroacetic Acid SCHEMBL3028190 | 0.84 | CYP3A4 (0.39) | CYP3A4EPAS1 | |
| SCHEMBL13982108 | 0.83 | MEN1 (0.38) | KLKB1 | |
| SCHEMBL3017381 | 0.83 | CYP3A4 (0.49) | CYP3A4 | |
| SCHEMBL3027159 | 0.83 | CYP3A4 (0.54) | CYP3A4SCN9AEPAS1SLC22A12 | |
| SCHEMBL3027526 | 0.83 | CYP3A4 (0.46) | CYP3A4SCN9AEPAS1 | |
| Trifluoroacetic Acid SCHEMBL3023663 | 0.82 | CYP3A4 (0.42) | CYP3A4EGLN2EGLN1F3EPAS1 | |
| Trifluoroacetic Acid SCHEMBL13560603 | 0.82 | CYP3A4 (0.42) | CYP3A4EGLN2EGLN1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | CYP3A4 169/4885EGLN2 2951/4885EGLN1 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.