Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.69 |
| ▸ | MELK | Q14680 | 2/20 | 0.69 |
| ▸ | JAK1 | P23458 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.50 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25233916 | 1.00 | JAK3 (0.69) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL21409411 | 0.90 | JAK3 (0.73) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL30281597 | 0.90 | JAK3 (0.73) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL3977917 | 0.85 | JAK3 (0.64) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL28348803 | 0.79 | JAK3 (1.00) | JAK3MELKJAK1JAK2BTK | |
| SCHEMBL28080559 | 0.76 | JAK3 (0.74) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL24804956 | 0.76 | JAK3 (0.72) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL20184394 | 0.74 | JAK3 (0.69) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL28348684 | 0.74 | JAK3 (0.69) | JAK3MELKJAK1ROCK2CYP3A4 | |
| SCHEMBL3127395 | 0.74 | ROCK2 (1.00) | JAK3MELKROCK2CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116589467-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-116589466-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| EP-4146655-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BeiGene, Ltd. (KY) | 2023-03-15 | — | — | EP | disclosed |
| CN-115485278-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2022-12-16 | — | — | CN | disclosed |