Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401008 | 0.81 | KDM4E (0.67) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL30472092 | 0.80 | KDM4E (0.62) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL12369729 | 0.79 | PPARA (0.72) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL12396054 | 0.76 | PPARA (0.82) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL3481292 | 0.76 | CYP1A2 (0.66) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL19080613 | 0.75 | L3MBTL1 (0.65) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL14349556 | 0.73 | CHRNB2 (0.63) | TSHRPPARAALDH1A1RAB9ANPC1 | |
| SCHEMBL15504856 | 0.72 | MAPK1 (0.59) | MAPK1TSHRPPARAL3MBTL1ALDH1A1 | |
| SCHEMBL4107632 | 0.72 | RAB9A (0.76) | MAPK1TSHRL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL2657248 | 0.70 | CHRNB2 (0.69) | TSHRPPARAL3MBTL1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143179-A1 | AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2023-03-08 | — | — | EP | claimed |
| EP-4143179-A1 | AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2023-03-08 | — | — | EP | disclosed |