Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 5/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ARF6 | P62330 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25305119 | 1.00 | MAT2A (0.58) | MAT2AGABRA1GABRG2GABRB3GRIN2D | |
| SCHEMBL25305158 | 0.86 | MAT2A (0.58) | MAT2AGABRA1GABRG2GABRB3GRIN2D | |
| SCHEMBL30319976 | 0.76 | MAT2A (0.71) | MAT2AGABRA1GABRG2GABRB3MAPK14 | |
| SCHEMBL24155083 | 0.76 | MAT2A (0.71) | MAT2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL25304498 | 0.73 | MAT2A (0.70) | MAT2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL24110060 | 0.73 | MAT2A (1.00) | MAT2A | |
| SCHEMBL25303327 | 0.64 | MAT2A (0.57) | MAT2APIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL22093374 | 0.64 | MAT2A (0.69) | MAT2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL30499832 | 0.64 | MAT2A (0.69) | MAT2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL24109648 | 0.62 | MAT2A (0.80) | MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867541-A | Aminopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-115867541-A | Aminopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-03-28 | — | — | CN | disclosed |