Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 11/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30319976 | 0.86 | MAT2A (0.71) | MAT2AMAPK14DHODHMAPK13MAPK12 | |
| SCHEMBL25304498 | 0.83 | MAT2A (0.70) | MAT2AMAPK14DHODHMAPK13MAPK12 | |
| SCHEMBL24110060 | 0.83 | MAT2A (1.00) | MAT2A | |
| SCHEMBL24109554 | 0.78 | MAT2A (0.71) | MAT2A | |
| SCHEMBL29893575 | 0.78 | MAT2A (0.71) | MAT2A | |
| SCHEMBL25304687 | 0.76 | MAT2A (0.59) | MAT2AMAPK14DPP4DPP8 | |
| SCHEMBL30283151 | 0.76 | MAT2A (0.58) | MAT2AMAPK14DHODHMAPK13MAPK12 | |
| SCHEMBL25305119 | 0.76 | MAT2A (0.58) | MAT2AMAPK14DHODHMAPK13MAPK12 | |
| SCHEMBL25305158 | 0.76 | MAT2A (0.58) | MAT2AMAPK14DHODHMAPK13MAPK12 | |
| SCHEMBL25262967 | 0.75 | MAT2A (0.50) | MAT2AMAPK14DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227449-A1 | AMIDOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230227449-A1 | AMIDOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-07-20 | — | — | US | disclosed |
| WO-2021259815-A1 | AMIDOPYRIMIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227449-A1 | AMIDOPYRIMIDONE DERIVATIVES | F12, XDH, CYP3A43 | MAT2A 4385/4885MAPK14 3173/4885DHODH 2612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.