Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 3/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30283490 | 0.92 | ROCK1 (0.38) | PARP15PARP10ROCK1BRD4TOP1 | |
| SCHEMBL30283588 | 0.84 | GPR3 (0.40) | PARP15PARP10ROCK1BRD4IP6K1 | |
| SCHEMBL30283654 | 0.81 | ALDH1A1 (0.41) | PARP15PARP10ROCK1BRD4TOP1 | |
| SCHEMBL30283486 | 0.81 | ROCK1 (0.36) | PARP15PARP10ROCK1BRD4AAK1 | |
| SCHEMBL30283807 | 0.80 | PARP15 (0.40) | PARP15PARP10ROCK1AAK1 | |
| SCHEMBL30283611 | 0.79 | TDO2 (0.36) | PARP15PARP10ROCK1BRD4AAK1 | |
| SCHEMBL31719876 | 0.78 | ALDH1A1 (0.44) | ROCK1BRD4KMT2A | |
| SCHEMBL31719986 | 0.77 | PARP15 (0.35) | PARP15PARP10ROCK1PARP1 | |
| SCHEMBL30283579 | 0.76 | GPR3 (0.42) | PARP15PARP10ROCK1BRD4IP6K1 | |
| SCHEMBL31719864 | 0.74 | PARP15 (0.39) | PARP15PARP10IP6K1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034344-A1 | ISOQUINOLINONES AND QUINOLINONES AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |