Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30283853 | 0.92 | ROCK1 (0.39) | ROCK1ALDH1A1TACR1ROCK2MAPT | |
| SCHEMBL30283845 | 0.89 | ROCK1 (0.36) | ROCK1ROCK2BRD4CDK2GSK3B | |
| SCHEMBL30283588 | 0.83 | GPR3 (0.40) | ROCK1ALDH1A1MAPTMEN1CYP2C19 | |
| SCHEMBL30283418 | 0.81 | ROCK1 (0.40) | ROCK1ALDH1A1TACR1ROCK2BRD4 | |
| SCHEMBL30228019 | 0.78 | CA12 (0.41) | — | |
| SCHEMBL30283776 | 0.74 | MAOB (0.37) | ROCK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL30283579 | 0.74 | GPR3 (0.42) | ROCK1ALDH1A1CYP2C19BRD4 | |
| SCHEMBL30283552 | 0.72 | PARP15 (0.36) | ROCK1KMT2ABRD4 | |
| SCHEMBL30283286 | 0.71 | PRKCB (0.46) | ROCK1ALDH1A1ROCK2BRD4 | |
| SCHEMBL30283640 | 0.71 | ROCK1 (0.47) | ROCK1ALDH1A1ROCK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034344-A1 | ISOQUINOLINONES AND QUINOLINONES AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |