Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11194151 | 0.99 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR | |
| SCHEMBL11195815 | 0.89 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR | |
| Hydrochloric Acid SCHEMBL11190936 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR | |
| Hydrochloric Acid SCHEMBL11182084 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR | |
| SCHEMBL11191223 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1CNR1TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL11179893 | 0.87 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2TSHRCASR | |
| Hydrochloric Acid SCHEMBL11195804 | 0.84 | NPSR1 (0.50) | ALDH1A1NPC1RAB9ALMNAMEN1 | |
| SCHEMBL11190681 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2TSHRCASR | |
| SCHEMBL11182832 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR | |
| SCHEMBL11184801 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2CNR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004561-B1 | UREA AND AMIDE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICALS CONTAINING THEM AND THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS | CIBA-GEIGY AG (CH) | 1981-11-04 | — | — | EP | claimed |
| US-20100216817-A1 | Antitumoral Tetrahydro-Pyrimidines | PHARMA MAR SA (ES) | 2010-08-26 | — | — | US | disclosed |
| EP-1879870-A1 | ANTITUMORAL TETRAHYDRO-PYRIMIDINES | Pharma Mar, S.A. (ES) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117197-A1 | ANTITUMORAL TETRAHYDRO-PYRIMIDINES | PHARMA MAR, S.A. (ES) | 2006-11-09 | — | — | WO | disclosed |
| US-4420619-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1983-12-13 | — | — | US | disclosed |
| US-4292429-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216817-A1 | Antitumoral Tetrahydro-Pyrimidines | TYMS, TYMP, MRM1 | KDM4E 3436/4885ALDH1A1 1217/4885SMN1; SMN2 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.