Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562144 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| Iodide SCHEMBL5948853 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| SCHEMBL6344200 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| SCHEMBL6562435 | 0.84 | NPC1 (0.50) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| SCHEMBL6561361 | 0.83 | L3MBTL1 (0.54) | LMNAHTTGSK3BL3MBTL1MEN1 | |
| Iodide SCHEMBL5949437 | 0.83 | NPC1 (0.49) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5949500 | 0.82 | KMT2A (0.47) | SMN1; SMN2LMNAHTTGSK3BL3MBTL1 | |
| SCHEMBL6561756 | 0.82 | PARP1 (0.42) | SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1 | |
| Iodide SCHEMBL5949473 | 0.82 | L3MBTL1 (0.53) | LMNAHTTGSK3BL3MBTL1MEN1 | |
| Iodide SCHEMBL5949290 | 0.81 | PARP1 (0.41) | SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197740-A1 | Method of Screening Compounds Having Anti-Amyloid Properties | LES LABORATOIRES SERVIER (FR) | 2010-08-05 | — | — | US | disclosed |