Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5949437 | 0.98 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL6345616 | 0.90 | NPC1 (0.42) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL6561361 | 0.86 | L3MBTL1 (0.54) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL2562144 | 0.86 | SMN1; SMN2 (0.47) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| Iodide SCHEMBL5949473 | 0.84 | L3MBTL1 (0.53) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| Iodide SCHEMBL5948853 | 0.84 | SMN1; SMN2 (0.46) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3028583 | 0.84 | SMN1; SMN2 (0.46) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL6561467 | 0.83 | HAO1 (0.42) | NPC1RAB9AKMT2AL3MBTL1KDM4E | |
| SCHEMBL6562162 | 0.83 | KMT2A (0.53) | NPC1RAB9AKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL6560757 | 0.83 | MAPT (0.47) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1050531-B1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | SERVIER LAB (FR) | 2004-11-17 | — | — | EP | disclosed |
| EP-1050531-A1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | ADIR ET COMPAGNIE (FR) | 2000-11-08 | — | — | EP | disclosed |