Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31477868 | 0.84 | HRH4 (0.37) | CYP1A2CYP2C9CYP2C19GAAHRH4 | |
| SCHEMBL11526524 | 0.79 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL12932880 | 0.78 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL5026036 | 0.76 | CYP3A4 (0.51) | ALDH1A1CYP1A2CYP2C9CYP2C19RAPGEF4 | |
| SCHEMBL10994173 | 0.76 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL4546556 | 0.73 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL11528767 | 0.72 | THRB (0.52) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL30288240 | 0.72 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL21723459 | 0.71 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD | |
| SCHEMBL30288271 | 0.71 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, MPST, CRAT | ALDH1A1 215/4885L3MBTL1 4267/4885CYP1A2 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.