Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278531 | 0.92 | HTT (0.57) | LMNAALDH1A1MAPTCACNA1HHTT | |
| SCHEMBL302890 | 0.88 | HTT (0.51) | LMNAALDH1A1MAPTCACNA1HHTT | |
| SCHEMBL3377793 | 0.88 | MAPT (0.64) | LMNAALDH1A1MAPTHTTGAA | |
| SCHEMBL1967123 | 0.87 | LMNA (0.68) | LMNAALDH1A1MAPTHTTGAA | |
| SCHEMBL1965535 | 0.84 | MAPT (0.57) | LMNAALDH1A1MAPTCACNA1HHTT | |
| SCHEMBL3378728 | 0.82 | MAPT (0.70) | LMNAALDH1A1MAPTHTTGAA | |
| SCHEMBL3377228 | 0.81 | MAPT (0.74) | LMNAALDH1A1MAPTHTTGAA | |
| SCHEMBL301695 | 0.80 | GAA (0.76) | LMNAALDH1A1MAPTCACNA1HHTT | |
| SCHEMBL3279971 | 0.79 | MAPT (0.61) | LMNAALDH1A1MAPTCACNA1HHTT | |
| SCHEMBL2189346 | 0.78 | LMNA (0.85) | LMNAALDH1A1MAPTHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |