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SCHEMBL1965535

SCHEMBL1965535

COCC(=O)Nc1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1.O=C(Cc1ccccc1)Nc1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 11/20 0.57
▸ LMNA P02545 6/20 0.57
▸ TP53 P04637 1/20 0.55
▸ THRB P10828 1/20 0.55
▸ CACNA1H O95180 1/20 0.54
▸ HTT P42858 2/20 0.52
▸ GAA P10253 1/20 0.52
▸ USP2 O75604 1/20 0.50
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3279971 0.96 MAPT (0.61) MAPTLMNATP53THRBCACNA1H
SCHEMBL3278531 0.92 HTT (0.57) MAPTLMNATP53THRBCACNA1H
SCHEMBL302890 0.86 HTT (0.51) MAPTLMNATP53THRBCACNA1H
SCHEMBL302889 0.84 LMNA (0.54) MAPTLMNACACNA1HHTTGAA
SCHEMBL301695 0.82 GAA (0.76) MAPTLMNACACNA1HHTTGAA
SCHEMBL1964073 0.78 GAA (0.55) MAPTLMNATP53THRBCACNA1H
SCHEMBL3235765 0.77 CACNA1H (0.51) MAPTLMNATP53THRBCACNA1H
SCHEMBL1965537 0.76 MAPT (0.49) MAPTLMNATP53THRBCACNA1H
SCHEMBL8547733 0.74 MAPT (0.71) MAPTLMNATP53THRBHTT
SCHEMBL3377228 0.74 MAPT (0.74) MAPTLMNAHTTGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334637-A1 NOVEL POTASSIUM CHANNEL BLOCKERS Xention Limited (GB) 2011-06-22 — — EP disclosed