Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278531 | 0.94 | HTT (0.57) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL302889 | 0.88 | LMNA (0.54) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL1965535 | 0.86 | MAPT (0.57) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL1964511 | 0.84 | MEN1 (0.62) | HTTGAALMNAALDH1A1L3MBTL1 | |
| SCHEMBL301695 | 0.81 | GAA (0.76) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL3279971 | 0.81 | MAPT (0.61) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL3454266 | 0.78 | EPHX2 (0.69) | HTTGAAMAPTLMNAALDH1A1 | |
| SCHEMBL1964073 | 0.76 | GAA (0.55) | HTTGAAMAPTCACNA1HLMNA | |
| SCHEMBL3377228 | 0.76 | MAPT (0.74) | HTTGAAMAPTLMNAALDH1A1 | |
| SCHEMBL3377793 | 0.75 | MAPT (0.64) | HTTGAAMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |