Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | USP19 | O94966 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385886 | 0.86 | SMN1; SMN2 (0.50) | USP19HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27224954 | 0.86 | DRD2 (0.59) | DRD2PDE4BKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7657420 | 0.86 | SMN1; SMN2 (0.50) | USP19HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20339027 | 0.83 | PARP1 (0.46) | PDE4BKMT2AUSP19HTTNPC1 | |
| SCHEMBL27039636 | 0.82 | DRD2 (0.49) | DRD2PDE4BKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL28429223 | 0.81 | USP19 (0.55) | KMT2AUSP19NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL951538 | 0.81 | KMT2A (0.59) | PDE4BKMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL25426557 | 0.81 | SMN1; SMN2 (0.45) | KMT2AL3MBTL1USP19HTTNPC1 | |
| SCHEMBL27039446 | 0.81 | DRD2 (0.48) | DRD2PDE4BKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL28437662 | 0.81 | USP19 (0.56) | KMT2AUSP19NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |