Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437662 | 0.99 | USP19 (0.56) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL25251265 | 0.90 | SMN1; SMN2 (0.49) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7657420 | 0.85 | SMN1; SMN2 (0.50) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4385886 | 0.85 | SMN1; SMN2 (0.50) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3902852 | 0.83 | SMN1; SMN2 (0.56) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL20339027 | 0.82 | PARP1 (0.46) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL8386105 | 0.82 | KMT2A (0.52) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL30288951 | 0.81 | DRD2 (0.52) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28435744 | 0.81 | SMN1; SMN2 (0.54) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL25426557 | 0.81 | SMN1; SMN2 (0.45) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098886-B | Prazinone-containing quinazolinone PARP-1/2 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-07-14 | — | — | CN | disclosed |