Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 6/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | F13A1 | P00488 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264129 | 0.89 | ALDH1A1 (0.62) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL18123354 | 0.85 | ALDH1A1 (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL31628389 | 0.81 | MEN1 (0.55) | ALDH1A1GRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL3744158 | 0.81 | CASP3 (0.45) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL31334311 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL31334638 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL30289225 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL15873777 | 0.80 | ALDH1A1 (0.60) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL15873821 | 0.80 | ALDH1A1 (0.60) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL16604750 | 0.80 | ALDH1A1 (0.63) | ALDH1A1GAACTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |