Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 4/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.48 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158130 | 0.90 | ALDH1A1 (0.49) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL30289381 | 0.89 | ALDH1A1 (0.53) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL15233277 | 0.87 | ALDH1A1 (0.58) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL19898223 | 0.86 | ALDH1A1 (0.64) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL4270198 | 0.84 | ALDH1A1 (0.49) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL12096431 | 0.84 | ALDH1A1 (0.49) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL4270200 | 0.84 | ALDH1A1 (0.49) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL4083850 | 0.84 | ALDH1A1 (0.49) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL562870 | 0.84 | ALDH1A1 (0.68) | ALDH1A1GAATSHREPHX1KDM1A | |
| SCHEMBL381922 | 0.83 | ALDH1A1 (0.85) | ALDH1A1GAATSHREPHX1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541468-B2 | Process of preparing N-ureidoalkyl-piperidines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-02 | — | — | US | disclosed |
| US-7351720-B2 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-01 | — | — | US | disclosed |
| EP-1817310-A1 | (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO-ONCOGENE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006034015-A1 | (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO- ONCOGENE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | OSI PHARMACEUTICALS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | KIT, BRDT, MALT1 | ALDH1A1 488/4885GAA 3044/4885TSHR 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.