SCHEMBL30289586

SCHEMBL30289586

COc1ccc(CN(Cc2ccc(OC)cc2)c2nccc3cnc(-c4ccc(Oc5ccccc5F)cc4)n23)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 11/20 0.44
LPAR5 Q9H1C0 11/20 0.44
MEN1 O00255 2/20 0.39
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SYK P43405 1/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 1/20 0.36
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36
CYP1A2 P05177 1/20 0.36
CHRM2 P08172 1/20 0.36
CYP3A4 P08684 1/20 0.36
HTR1A P08908 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30289595 0.90 LPAR1 (0.38) LPAR1LPAR5MEN1ALDH1A1KMT2A
SCHEMBL30289647 0.89 CYP1A2 (0.40) MEN1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL30289608 0.88 MEN1 (0.43) MEN1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL30289633 0.84 CETP (0.37) MEN1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL30289703 0.82 MEN1 (0.39) MEN1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL30289624 0.81 CETP (0.37) LPAR1LPAR5MEN1ALDH1A1KMT2A
SCHEMBL30367508 0.78 LMNA (0.42) MEN1ALDH1A1KMT2AHPGDRAB9A
SCHEMBL30289651 0.76 FYN (0.61) MEN1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL30289701 0.65 LMNA (0.44) MEN1ALDH1A1KMT2ASMN1; SMN2LMNA
SCHEMBL30289642 0.63 ABL1 (0.61) MEN1ALDH1A1KMT2AKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894497-A Imidazopyrimidine compounds, and preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2023-04-04 CN disclosed