Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ASPH | Q12797 | 3/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | AGER | Q15109 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16375222 | 1.00 | KMO (0.38) | KMONR1H4BACE1KDM4EASPH | |
| SCHEMBL16375219 | 0.87 | POLB (0.36) | NR1H4BACE1MRGPRX4CYP1A2ALDH1A1 | |
| SCHEMBL16375223 | 0.77 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL31245536 | 0.76 | BACE1 (0.33) | BACE1KDM4EASPHKDM8MAPT | |
| SCHEMBL21957976 | 0.76 | BACE1 (0.33) | BACE1KDM4EASPHKDM8MAPT | |
| SCHEMBL17986906 | 0.75 | KDM4E (0.53) | BACE1KDM4EMAPTCYP1A2ALDH1A1 | |
| SCHEMBL29770728 | 0.75 | KDM4E (0.53) | BACE1KDM4EMAPTCYP1A2ALDH1A1 | |
| SCHEMBL18149947 | 0.75 | KDM4E (0.41) | KMOKDM4EASPHKDM8MAPT | |
| SCHEMBL16375218 | 0.74 | MAPK14 (0.40) | CYP1A2ALDH1A1CYP3A4TSHRL3MBTL1 | |
| SCHEMBL31116809 | 0.73 | KDM4E (0.40) | KMOKDM4EASPHKDM8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698481-B | Heteroaryl pyridone and aza-pyridone amide compounds | 豪夫迈·罗氏有限公司 | 2023-02-28 | — | — | CN | disclosed |